"The four key symptoms of CFS are:

• the pain
• the brain
• the energy drain, and
• oh, I wish I could sleep again."        

Dr. Charles Lapp
Director: Hunter-Hopkins Centre, Charlotte, North Carolina
Advisory Committe for CFS:  US Department of Health & Human Services
Board of Directors:  American Association for Chronic Fatigue Syndrome

Post-Exertional Malaise and/or Fatigue

• Cracking the Foundation:  The Pacific Lab & Chronic Fatigue Syndrome (ME/CFS)
  Cort Johnson,  Phoenix Rising  04/2009 
• Post-Exertional Malaise
  Marj van de Sande
• Mobility Problems with ME
  Dr. Elizabeth Dowsett
  http://www.25megroup.org/Information/Medical/dowsett%27s/mobility%20problems.htm
  

Sleep

• Special Feature on sleep problems
  Dr. Elizabeth Dowsett, 25% M.E. Group
  

Pain

•  "There is a cultural problem where it's thought that there is a benefit from suffering. We have to get over this. It's not acceptable for people to suffer significant pain in the 21st century." Irene Tracey, Nuffield professor of anaesthetic science at Oxford University
  Pain 'Should be Viewed as a Disease in its Own Right' 03/2010
  Jane Dreaper, Health Correspondent, BBC News
  http://news.bbc.co.uk/2/hi/health/8543561.stm
  

• Genetic bases for chronic pain discovered  2006
  CFIDS
• Gateways to Pathological Pain  4/2005
  Jill Adams,  The Scientist.com
• New Clues to Understanding Chronic Pain Found   04/2005
  Dr. Joyce DeLeo, Dartmouth Medical School
  

• Brain Fog - Poor Memory, Difficulty Thinking Clearly, etc.   03/2010
  Dr. Sarah Myhill,  http://www.drmyhill.co.uk 
  http://www.drmyhill.co.uk/wiki/Brain_fog_-_poor_memory,_difficulty_thinking_clearly_etc
• 
  

• Brain Fog & Need for Good Energy Supply to the Brain   Dr. Sarah Myhill   ProHealth 02/10 The energy supply allows the brain to work quickly and efficiently. If energy is impaired, the first stage is fog. But if it progresses the result is dementia.She explains the factors affecting blood, oxygen and fuel supply to the brain. These include mitochondrial function, the nerves' myelin sheath function, brain fats & oils, and ways the brain may be poisoned.  read more

• Neurocognitive Impairment in CFS
  Dr. John DeLuca,  Co-cure
  
• Cognitive Function in ME/CFS:  Information for ME/CFS Physicians
  Dr. Eleanor Stein
  
• Neurocognitive Impairment in CFS
• The Blood-Brain Barrier & Its Possible Connection to ME/CFS  20
  Dr. Alan Logan
• Chronic Fatigue Syndrome Versus Depression  
  Dr. Pierre Flor-Henry

Autonomic Manifestations

• At the Heart of the Matter?  A Guide to Cardiac Issues in Chronic Fatigue Syndrome (ME/CFS)   June 2009
  Cort Johnson    Phoenix Rising
  
• CFS - The Central Cause:  Mitochondrial Failure  Updated 01/2009
  "Energy is supplied to cells by mitochondria which I think of as little engines which power every cell in the body.  When mitochondria fail ... all organs go slow."  Dr. Sarah Myhill 
• The Symptom of Orthostatic Intolerance in Chronic Fatigue Syndrome
  Dr. David Bell     Quest 68  2006
  
• Cardiac Insuffiency Hypothesis
  ME Society of America
  
• Orthostatic Intolerance
  Dr. David Bell     
  
• Diminished Cardiopulmonary Capacity During Post-Exertional Malaise
  Dr. Mark VanNess, Dr. Christopher Snell, Staci Stevens 
  
• Tricky Heart May Cause ME/CFS
   Dr. Daniel DeNoon, reviewed by Dr. Michael Smith,  WebMD
  
  

Neuroendocrine Dysfunctions

• The Role of the Hypothalamus
  Dr. Jacob Teitelbaum
  Co-Cure     www.co-cure.org   
  
  

Immune Dysfunction

• CFS Immune Dysfunction De Meirleir  2006
  Dr. Kenny De Meirleir